Cisplatin toxicity prevention

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August undefined, 2024

WebChemotherapy is one of the most important treatment methods, especially for advanced NSCLC. 3 We conducted clinical retrospective observational analyses to observe the curative effect and toxicity of cisplatin in combination with gemcitabine or Abraxane as first-line chemotherapy for stage III/IV NSCLC. Patients and methods. Clinical data WebMar 15, 2024 · Cisplatin and other platinum salt agents, including carboplatin and oxaliplatin, are widely used chemotherapy agents in patients with solid malignancies. …

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WebStrategies to prevent cisplatin ototoxicity have utilized antioxidants, transport inhibitors, G-protein receptor agonists, and anti-inflammatory agents. There are no FDA-approved drugs to prevent cisplatin ototoxicity. It is critical that potential protective agents do not interfere with the antitumor efficacy of cisplatin. WebSep 20, 2024 · Patients were randomized (1:1) to receive cisplatin-based chemotherapy with or without sodium thiosulfate administered at various doses of 10 g/m2, 15 g/m2, or … bismuth strontium titanate ceramic

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WebAbstract. Cisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. … WebJun 21, 2024 · Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival. WebCisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which … bismuth subcarbonate fine

Cisplatin Side Effects: Common, Severe, Long Term - Drugs.com

Mechanisms of Cisplatin-Induced Ototoxicity and …

WebCombined cisplatin, ifosfamide and bleomycin (PIB) chemotherapy was given to 14 (11 recurrent and 3 advanced and metastatic) cervical carcinoma patients. At least 2 cycles of chemotherapy were given before assessment of tumour response. The overall response rate was 28.6%; the complete response rate … WebApr 26, 2024 · Amifostine has FDA-approved labeling for use in reducing cumulative renal toxicity in patients receiving repeat doses of cisplatin for advanced ovarian cancer and … bismuth stricturesWebCisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast … darmowy pakiet microsoft office

"WebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion … " - Cisplatin toxicity prevention

Cisplatin toxicity prevention

Mechanisms of Cisplatin-Induced Ototoxicity and Prevention

WebApr 12, 2024 · Progression-free survival (PFS) was 8 and 5 months in the cisplatin plus gemcitabine cohort and the gemcitabine cohort (p < .001), respectively. 4 Based on the …

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WebNephrotoxicity is another major toxicity caused by cisplatin treatment. Kidney plays an important role as the main route of cisplatin excretion. Evidence from past studies has … WebThe principle of action of Cisplatin in combating cancer involves exerting its cytotoxicity upon cancer cells through the formation of DNA adducts that include mono-, inter, and intrastrand cisplatin DNA cross-links that arrest the cell cycle at S, G1 or G2-M thus induces apoptosis.

National Center for Biotechnology Information WebChemotherapy is one of the most important treatment methods, especially for advanced NSCLC. 3 We conducted clinical retrospective observational analyses to observe the …

WebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral … WebNov 12, 2024 · Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.Nausea and Vomiting: cisplatin injection can cause severe nausea and …

WebAbstract Purpose: Cisplatin (CP)-induced nephrotoxicity is associated with the increased generation of reactive oxygen metabolites and lipid peroxidation in kidney, caused by the decreased levels of antioxidants and antioxidant enzymes.

WebDec 1, 2024 · Dietary intervention is one of the anticipation ways for prevention of anti-cancer-related toxicity to minimize the harmful effects of cisplatin. Natural products or … bismuth structureWebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of … bismuth structure with space groupWebDec 19, 2024 · To develop a clinical practice guideline for the prevention of cisplatin-induced ototoxicity in children and adolescents with cancer, we convened an … darmowy office windows 11WebReductions in antioxidant capacity with respect to corresponding controls were also restored by OLE treatment. These findings suggest that the OLE treatment against cisplatin-induced toxicity improves the function of blood cells and helps them to survive in the belligerent environment created by free radicals. darmowy office dla firmWebAdverse effects of RT-CT were grades 3 to 4 neutropenia (four patients) and grade 3 esophageal toxicity (one patient). No treatment-related deaths occurred. Conclusion: The oral vinorelbine-cisplatin combination with concurrent RT is feasible and has a favorable risk-benefit ratio in stage IIIA/IIIB NSCLC. darmowy internet t mobileWebFeb 22, 2024 · Cisplatin is a known nephrotoxic agent, so reducing its concentration to get a similar toxicity profile in NSCLC cells is advantageous. For the two normal lung cell lines ( Figure 4 A,B), while the Lipo-PEITC-CDDP caused the lowest survival percentages, 59.0 ± 15.7% and 71.5 ± 11.0% for WI-38 and BEAS-2B, respectively, the cytotoxic effect of ... darmowy pdf converterWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … darmowy kreator pdf online